烯烃
氢胺化
分子内力
对映选择合成
催化作用
化学
组合化学
有机合成
分子间力
有机化学
胺化
铜
分子
作者
Sherry R. Chemler,Jonathan J. Kennedy-Ellis
标识
DOI:10.1055/sos-sd-238-00052
摘要
Abstract Alkene difunctionalization is a classic molecular transformation in organic synthesis, enabling the production of more-complex molecules from simple hydrocarbon-derived feedstocks. Alkene difunctionalizations catalyzed by copper complexes offer potentially more-sustainable protocols compared to those catalyzed by more-precious or -toxic metals. This chapter summarizes important recent advancements in the field, especially in the area of asymmetric catalysis. A number of copper-catalyzed intramolecular and intermolecular alkene difunctionalizations for the synthesis of cyclic and acyclic chiral amines and ethers, and related compounds, are presented. The reactions include alkene and/or diene hydroamination, hydroetherification, carboamination, carboetherification, diamination, oxyamination, and dicarbofunctionalization. Many of the reaction mechanisms involve a radical component either in the first or second bond-forming event. The ability of copper to engage with radicals in bond-forming events, including enantioselective ones, is a valuable aspect of many of these reactions.
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