Abstract PS02-07: Effectiveness of 24-week mobile application based human coaching program for controlling weight, BMI and body composition in overweight/obese breast cancer survivors: Single-arm prospective cohort study

Abstract Background: Overweight/obesity has been known as a prognostic factor for breast cancer recurrence and breast cancer related death. However, weight control is hard in breast cancer survivors because of menopause, chemotherapy, anti-hormonal therapy, and psychologic issues. This study aimed to develop 24-week mobile application based human coaching program with Noom and evaluate its efficacy in overweight/obese breast cancer survivors. Methods In this single-arm prospective cohort study, 130 breast cancer survivors with BMI ≥25 were enrolled and received 24-week program including diet-,exercise-, and psychology-based contents with trained human coach in Noom during 2019-2021. For hyperactive group who joined more than 16 weeks, we evaluated weight, BMI, lipid level, bioimpedance, and Quality of Life (QoL) at baseline, 6 month and 12month follow-up. Results Among 130 breast cancer survivor, 101 participants (77.7%) and 93 participants (71.5%) completed 6 month and 12 month follow-up, respectively. In hyperactive group (68/101, 67%), body weight and BMI reduced significantly (mean difference: -1.97 kg, 95% CI (confidence interval):-2.65- -1.26, P< 0.001 and -0.86, 95% CI:-1.15- -0.56, P< 0.001, respectively) at 6 month and maintained at 12 month without the yo-yo effect. Among the lipid panel, triglycerides level decreased significantly (-34.13, 95% CI:-58.09- -10.17, P=0.006) and maintained at 12 month. In the aspect of bioimpedance components, skeletal muscle mass (SMM, kg), body fat mass (BFM, kg), percent body fat (PBF, %), waist-hip ratio (WHR), and visceral fat area (VFA, cm2) were improved for first 6 months. However, WHR and VFA increased during next 6months. Based on the EORTC QLQ C30 and BR 23, nausea/vomiting, constipation, body image, arm and breast symptoms showed significant improvement during the first 6monts. Conclusions This study demonstrated that 24-week mobile application based human coaching program is beneficial for controlling body weight, BMI, TG and body composition in bioimpedance for overweigh/obsess breast cancer survivors. ClinicalTrials.gov NCT05506189; https://clinicaltrials.gov/ct2/show/ NCT05506189. IRB: NCC2019-0098 Citation Format: So-Youn Jung, Eun-Gyeong Lee, Dong-Eun Lee, Jeongseon Kim, Jai Hong Han, Seeyoun Lee, Han-Sung Kang, Eun Sook Lee, Heejung Chae, Sung Hoon Sim, Keun Seok Lee, Jungeun Lee. Effectiveness of 24-week mobile application based human coaching program for controlling weight, BMI and body composition in overweight/obese breast cancer survivors: Single-arm prospective cohort study [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PS02-07.