丘脑
神经科学
光遗传学
心理学
感觉系统
局部场电位
光刺激
功能连接
节奏
刺激
视觉感受
物理
感知
声学
作者
Wei Angel Huang,Zhe Zhou,Iain Stitt,Nivetha S. Ramasamy,Susanne Radtke‐Schuller,Flavio Fröhlich
标识
DOI:10.1016/j.cub.2023.12.067
摘要
Summary
Sustained visual attention allows us to process and react to unpredictable, behaviorally relevant sensory input. Sustained attention engages communication between the higher-order visual thalamus and its connected cortical regions. However, it remains unclear whether there is a causal relationship between oscillatory circuit dynamics and attentional behavior in these thalamo-cortical circuits. By using rhythmic optogenetic stimulation in the ferret, we provide causal evidence that higher-order visual thalamus coordinates thalamo-cortical and cortico-cortical functional connectivity during sustained attention via spike-field phase locking. Increasing theta but not alpha power in the thalamus improved accuracy and reduced omission rates in a sustained attention task. Further, the enhancement of effective connectivity by stimulation was correlated with improved behavioral performance. Our work demonstrates a potential circuit-level causal mechanism for how the higher-order visual thalamus modulates cortical communication through rhythmic synchronization during sustained attention.
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