生物
相扑蛋白
拟南芥
转录因子
抑制因子
螺旋
细胞生物学
遗传学
基因
功能(生物学)
转录调控
泛素
抄写(语言学)
计算生物学
DNA结合蛋白
哲学
突变体
语言学
作者
Fei Gao,Christian Dubos
标识
DOI:10.1016/j.tplants.2023.11.022
摘要
Basic helix-loop-helices (bHLHs) are present in all eukaryotes and form one of the largest families of transcription factors (TFs) found in plants. bHLHs function as transcriptional activators and/or repressors of genes involved in key processes involved in plant growth and development in interaction with the environment (e.g., stomata and root hair development, iron homeostasis, and response to heat and shade). Recent studies have improved our understanding of the functioning of bHLH TFs in complex regulatory networks where a series of post-translational modifications (PTMs) have critical roles in regulating their subcellular localization, DNA-binding capacity, transcriptional activity, and/or stability (e.g., protein-protein interactions, phosphorylation, ubiquitination, and sumoylation). Further elucidating the function and regulation of bHLHs will help further understanding of the biology of plants in general and for the development of new tools for crop improvement.
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