血管生成
纳米医学
血管内皮生长因子
医学
癌症
抗药性
药物输送
靶向治疗
药品
癌症研究
癌症治疗
联合疗法
靶向给药
药理学
纳米技术
血管内皮生长因子受体
生物
内科学
材料科学
纳米颗粒
微生物学
作者
Asmaa F. Khafaga,Mohamed M.S. Gaballa,Reham Karam,Salma A. Shoulah,Rehab Nabil Shamma,Norhan E. Khalifa,Nourihan S. Farrag,Ahmed E. Noreldin
出处
期刊:Life Sciences
[Elsevier]
日期:2024-03-01
卷期号:341: 122499-122499
标识
DOI:10.1016/j.lfs.2024.122499
摘要
Angiogenesis is one of the defining characteristics of cancer. Vascular endothelial growth factor (VEGF) is crucial for the development of angiogenesis. A growing interest in cancer therapy is being caused by the widespread use of antiangiogenic drugs in treating several types of human cancer. However, this therapeutic approach can worsen resistance, invasion, and overall survival. As we proceed, refining combination strategies and addressing the constraint of targeted treatments are paramount. Therefore, major challenges in using novel combinations of antiangiogenic agents with cytotoxic treatments are currently focused on illustrating the potential of synergistic therapeutic strategies, alongside advancements in nanomedicine and gene therapy, present opportunities for more precise interference with angiogenesis pathways and tumor environments. Nanoparticles have the potential to regulate several crucial activities and improve several drug limitations such as lack of selectivity, non-targeted cytotoxicity, insufficient drug delivery at tumor sites, and multi-drug resistance based on their unique features. The goal of this updated review is to illustrate the enormous potential of novel synergistic therapeutic strategies and the targeted nanoparticles as an alternate strategy for t treating a variety of tumors employing antiangiogenic therapy.
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