姜黄
姜黄素
代谢工程
姜科
工业与生产工程
抗菌剂
生物化学
雅罗维亚
微生物
化学
生物合成
生物技术
生物
根茎
酶
酵母
细菌
植物
有机化学
工程类
电气工程
遗传学
作者
Luyao Wang,Xue Han,Fengzhong Wang,Lichao Sun,Fengjiao Xin
出处
期刊:Chinese Journal of Biotechnology
日期:2021-02-25
卷期号:37 (2): 404-417
被引量:1
标识
DOI:10.13345/j.cjb.200286
摘要
Curcuminoids are rare diketone compounds in plants and can be found in the rhizome of Curcuma longa as well as other Zingiberaceae and Araceae. Curcuminoids have been widely used in food and medical area owing to the yellow colors, as well as the antioxidant and many other pharmacological activities. Curcuminoids are a mixture of compounds containing curcumin, demethoxycurcumin and bisdemethoxycurcumin, which have distinct benzene ring substituents. Currently, curcuminoids are exclusively produced through plant extraction, which do not satisfy the meeting of the market demand. Empowered with new synthetic biology tools and metabolic engineering strategies, there is renewed interest in production of curcuminoids using microorganisms. Heterologous production of curcuminoids has been achieved using Escherichia coli, Yarrowia lipolytica, Pseudomonas putida and Aspergillus oryzae via engineering of curcuminoids biosynthesis pathway. In this review, we first describe the biological activities and various applications of curcuminoids. Next, we summarize the biosynthetic pathway of curcuminoids in Curcuma longa and discuss the catalytic mechanisms of curcumin synthases. Then, we thoroughly explore recent advances in the use of distinct microorganisms for the production of curcuminoids with a special focus on metabolic engineering strategies. Finally, we prospect the microbial production of curcuminoids by highlighting some promising techniques and approaches.
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