化学
安息香
本齐尔
苄胺
芳构化
组合化学
羟甲基
细胞毒性T细胞
有机化学
体外
生物化学
催化作用
作者
Venkata Ramana Kandula,Mohanreddy Pothireddy,K. Suresh Babu,Ravikumar Kapavarapu,Rambabu Dandela,Manojit Pal
标识
DOI:10.1016/j.tetlet.2021.153011
摘要
The ultrasound assisted facile, rapid and one-pot synthesis of 2-aryl substituted 4,5-diphenyloxazoles was achieved via the reaction of commercially available benzoin (or 2-hydroxy-2-phenylacetophenone) with benzylamines in the presence of IBX under mild conditions. The methodology involved initial IBX mediated conversion of benzoin to benzil and then reaction with benzylamine followed by intramolecular cyclization (CO bond formation) and finally aromatization in the presence of air in the same pot. The methodology afforded a variety of desired products that were assessed for their cytotoxic properties against a number of cancerous and a non-cancerous cell lines. Compounds 3h, 3n and 3o showed promising growth inhibition of these cell lines except the non-cancerous one and interactions with SIRT1 in silico as well as in vitro.
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