Rhodium-Catalyzed Regio-, Diastereo-, and Enantioselective Three-Component Carboamination of Dienes via C–H Activation

Reported herein is the rhodium-catalyzed enantioselective three-component coupling of arene, diene, and dioxazolone that occurs via C–H activation en route to allyl intermediate. This carboamination reaction affords chiral allylic amines in 1,2-selectivity, E -selectivity, and enantioselectivity, with electrophilic amination of the π-allyl species being both regio- and enantio-determining.