医学
活力
心理健康
生活质量(医疗保健)
情感(语言学)
逻辑回归
多发性硬化
扩大残疾状况量表
疾病
横断面研究
精神科
老年学
内科学
心理学
病理
护理部
哲学
沟通
神学
作者
Irene Gil-González,María Ángeles Pérez-San-Gregorio,Rupert Conrad,Agustín Martín-Rodríguez
标识
DOI:10.1016/j.msard.2021.103093
摘要
Abstract
Background
Multiple sclerosis (MS) is a chronic neurodegenerative disease that can negatively affect functioning across a wide spectrum of domains. This study aims to investigate the development of mental health and quality of life in MS patients over 18-months and to identify predictive factors. Method
314 MS outpatients of Virgen Macarena University Hospital in Sevilla/Spain (mean age 45 years, 67.8% women, on average 12.1 years since diagnosis) participated in the study. Health-related quality of life (HRQOL) and mental health were assessed by the 12-Item Short Form Health Survey (SF-12) and the General Health Questionnaire-28 (GHQ-28) twice over an 18-months follow up period. Results
HRQOL and mental health significantly improved in almost all domains, except for a worsening of vitality. Mental and physical HRQOL improved by a large effect size. Binomial logistic regression models showed that disability status (Expanded Disability Status Scale) predicted both components of HRQOL and age the physical component of HRQOL. Sex, educational level, and disease duration predicted mental health. Conclusions
Our findings confirm the possibility of a significant large-sized improvement of HRQOL in the course of 18-months even 12 years after MS diagnosis on average. The study showed the importance of sociodemographic as well as clinical variables to predict HRQOL and mental health. Further longitudinal research is needed to better understand their impact on patients' outcomes.
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