A Multicenter, Open-Label Study of Combined Poly-L-Lactic Acid and Hyaluronic Midface Filler Regimen Enhances Facial Harmony and Skin Quality in GLP-1 Medication Users

Abstract Background Weight loss induced by glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can lead to facial volume loss, wrinkles, and sagging skin, resulting in an aged and gaunt appearance that negatively affects subject satisfaction and self-perception. Objectives This study assessed the treatment regimen of poly-L-lactic acid (PLLA-SCA) and 2 hyaluronic acid midface fillers (HA-LYF, HA-CON) on restoring facial balance, correcting contour deficiencies, and improving skin quality in subjects who experienced weight loss from GLP-1 RA therapy. Methods This multicenter, open-label study enrolled 41 subjects with cheek wrinkles and midface contour deficiencies following GLP-1 RA–driven weight loss. Subjects received 2 to 3 treatment sessions of PLLA-SCA and 1 to 2 treatment sessions of HA-LYF or HA-CON, with follow-ups through 9 months since the last PLLA-SCA treatment. Efficacy evaluations included objective skin quality assessments using bioinstrumentation, improvements in facial contour deficiencies using standardized photography, and subject self-assessment questionnaires. Safety was also monitored throughout the study. Results The PLLA-SCA and HA-LYF or HA-CON treatment regimen significantly improved facial skin quality and enhanced contour in the cheek, jawline, and perioral areas, and demonstrated objective improvement in hydration and skin radiance. Additionally, subjects were satisfied with the treatment results, with no treatment-related adverse events reported. Conclusions PLLA-SCA and HA-LYF or HA-CON provided effective, safe, and sustained improvements in facial balance, contour, and skin quality in subjects who experienced facial volume loss and aging from weight loss following GLP-1 RA therapy.