过氧化氢
癌细胞
荧光
鲁米诺
化学
纳米技术
光动力疗法
次氯酸盐
癌症
胶体金
肿瘤微环境
生物物理学
材料科学
纳米颗粒
生物化学
医学
生物
有机化学
内科学
物理
量子力学
作者
Yun Chen,Jing Yong Ye,Gang Lv,Weiwei Liu,Hui Jiang,Xiaohui Liu,Xuemei Wang
出处
期刊:Biosensors
[MDPI AG]
日期:2022-02-11
卷期号:12 (2): 111-111
被引量:5
摘要
Accurate diagnosis of cancer cells directly affects the clinical treatment of cancer and can significantly improve the therapeutic effect of cancer patients. Cancer cells have a unique microenvironment with a large amount of peroxide inside, effectively differentiated from relevant microenvironment normal cells. Therefore, designing the high-sensitive probes to recognize and distinguish the special physiological microenvironment of cancer cells can shed light on the early diagnosis of cancers. In this article, we design and construct a fluorescence (FL) contrast agent for cancer cell recognition and imaging analysis. Firstly, luminol-gold NPs (Lum-AuNPs) have been initially built, and then successfully loaded with the fluorescent receptor Chlorin e6 (Ce6) to prepare the luminescent nanoprobes (Ce6@Lum-AuNPs) with green synthesis, i.e., with biocompatible agents and mild temperature. The as-prepared fluorescent Ce6@Lum-AuNPs can efficiently and sensitively realize FL bioimaging of cancer cells. The relevant bio-sensing mechanism pertains to the presence of hypochlorite (ClO-); hydrogen peroxide (H2O2) in cancer cells could readily interact with luminol to produce chemiluminescence, which can activate the Ce6 component to emit near-infrared (NIR) FL. Therefore, this raises the possibility of utilizing the Ce6@Lum-AuNPs as efficient fluorescent nanoprobes for promising cancer early diagnosis and other relevant disease bioanalysis.
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