质粒
毒力
生物
微生物学
肠炎沙门氏菌
基因
多重耐药
拉伤
全基因组测序
抗生素耐药性
沙门氏菌
抗药性
基因组
遗传学
抗生素
细菌
解剖
作者
Weiwei Zhao,Ying Zhao,Xiaoping Luo,Rui Li,Min Zhou
出处
期刊:Foodborne Pathogens and Disease
[Mary Ann Liebert]
日期:2022-04-01
卷期号:19 (4): 293-296
标识
DOI:10.1089/fpd.2021.0096
摘要
A Salmonella Enteritidis clinical strain SAL045 isolated from an infant patient in China was subjected to whole genome sequencing. Strain SAL045 is resistant to 12 antibiotics tested including ampicillin and polymyxin E. A novel hybrid plasmid pS045A harboring 22 antibiotic resistance genes and 10 virulence genes was characterized. There were no sequences in the NCBI nucleotide database that completely covered the pS045A sequence. Sequence analysis indicated that pS045A was formed by IS26-mediated recombination of two plasmids. Plasmid pS045A was transferred to E. coli EC600 recipient strain at a frequency of 1.76 × 10-6 per donor cell. Plasmid pS045A is a novel conjugative plasmid and might cause dissemination of drug-resistance and virulence genes within enterobacterial species.
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