20(S)-Protopanaxadiol decreases atherosclerosis in ApoE KO mice by increasing the levels of LDLR and inhibiting its binding with PCSK9

Our results demonstrate that PPD directly binds to the extracellular domain of LDLR and inhibits the interaction between PCSK9 and LDLR, thereby increasing the levels of LDLR and alleviating atherosclerosis in HFD-fed ApoE KO mice.