自愈水凝胶
伤口愈合
PEG比率
壳聚糖
皮肤修复
弹性蛋白
聚乙二醇
药物输送
化学
药理学
生物医学工程
医学
外科
高分子化学
生物化学
病理
有机化学
财务
经济
作者
Jon Andrade del Olmo,José María Rabal Alonso,Virginia Sáez Martínez,Sandra Benito Cid,Mikel Azkune,Maialen Bengoa Larrauri,Raúl Pérez González,José Luis Vilas-Vilela,Leyre Pérez‐Álvarez
出处
期刊:Biomaterials advances
日期:2022-08-01
卷期号:139: 212992-212992
被引量:12
标识
DOI:10.1016/j.bioadv.2022.212992
摘要
Great efforts have been performed on the production of advanced biomaterials with the combination of self-healing and wound healing properties in implant/tissue engineering biomedical area. Inspired by this idea, chitosan (CHI) based hydrogels can be used to treat a less investigated class of harmful chronic wounds: ulcers or pressure ulcers. Thus, CHI was crosslinked with previously synthesized polyethylene glycol diacid (PEG-diacid) to obtain different CHI-PEG hydrogel formulations with high H-bonding tendency resulting in self-repair ability. Here presented results show biocompatible, antibacterial, anti-inflammatory, and self-healing CHI-PEG hydrogels with a promising future in the treatment of ulcerated wounds by a significant improvement in metabolic activity (94.51 ± 4.38 %), collagen and elastin quantities (2.12 ± 0.63 μg collagen and 4.97 ± 0.61 μg elastin per mg dermal tissue) and histological analysis. Furthermore, cefuroxime (CFX), tetracycline (TCN) and amoxicillin (AMX) antibiotics, and acetylsalicylic acid (ASA) anti-inflammatory agent were sustainedly released for enhancing antibacterial and anti-inflammatory activities of hydrogels.
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