医学
因子IX
甲氨蝶呤
凝血酶原时间
纤维蛋白原
血液学
D-二聚体
内科学
胃肠病学
凝结
因素七
淋巴细胞白血病
部分凝血活酶时间
外科
白血病
作者
Tunç Fışgın,Neşe Yaralı,Abdurrahman Kara,Ceyhun Bozkurt,Dilek Birgen,Ulya Erten,Feride Duru
标识
DOI:10.1080/pho.21.1.77.83
摘要
The purpose of this study is to investigate the hemostatic side effects of HDMTX. Between 2001 and 2002, 20 children with acute lymphoblastic leukemia at the Dr. Sami Ulus Children's Hospital, Department of Pediatric Hematology and Oncology, treated according to the St. Jude ALL XIII protocol were eligible to this study. Methotrexate at a dose of 2 g/m2was infused over 24 hours. Coagulation screening studies included prothrombin time (PT), APTT, fibrinogen, fibrin degradation product (D-Dimer), factor II, factor V, factor VII, factor VIII, factor IX, factor X, PC, PS, AT-III determinations before HDMTX therapy (PreT), 1 day after (PostT1D), and 1 week after (PostT1W) the end of the HDMTX infusion. We found that PT and APTT were prolonged, PC, PS, and AT-III levels were decreased with a slight increase in D-Dimer 1 day after the administration of HDMTX and all of them returned to the normal levels by 7 days. In addition we found that FVII, FIX, FX were significantly decreased 1 day after therapy and normalised by 7 days.
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