化学
细胞毒性
立体化学
细胞毒性T细胞
细胞培养
二维核磁共振波谱
癌细胞系
传统医学
癌细胞
药理学
生物化学
癌症
体外
生物
医学
遗传学
作者
Xiao‐Xiao Huang,Chenchen Zhou,Ling-Zhi Li,Feifei Li,Li‐Li Lou,Dianming Li,Takashi Ikejima,Ying Peng,Shao‐Jiang Song
标识
DOI:10.1016/j.bmcl.2013.08.045
摘要
Nine new 8-O-4' neolignans, named pinnatifidanin B I-IX (1-9), together with 9 known analogs (10-18) were isolated from the seeds of Crataegus pinnatifida. The structures of 1-18 were determined by spectroscopic methods, including 1D, 2D NMR, CD and HRESIMS analysis. Compounds 8-11, 17 and 18 displayed potent cytotoxic activities against human cancer cell lines, and most interestingly, none of the 6 compounds displayed inhibitory activity against human lung cell line (Mrc5). The 6 cytotoxic compounds are considered to be potential as antitumor agents, which could significantly inhibit the cancer cell growth in a dose-dependent manner and are probably safer than positive control drug.
科研通智能强力驱动
Strongly Powered by AbleSci AI