对映选择合成
烷基化
喹啉
催化作用
化学
铜
产量(工程)
烷基
组合化学
有机化学
材料科学
冶金
作者
Songjie Yu,Hui Leng Sang,Shaozhong Ge
标识
DOI:10.1002/anie.201709411
摘要
An asymmetric copper-catalyzed alkylation of quinoline N-oxides with chiral Cu-alkyl species, generated by migratory insertion of a vinylarene into a chiral Cu-H complex, is reported. A variety of quinoline N-oxides and vinylarenes underwent this Cu-catalyzed enantioselective alkylation reaction, affording the corresponding chiral alkylated N-heteroarenes in high yield with high-to-excellent enantioselectivity. This enantioselective protocol represents the first general and practical approach to access a wide range of chiral alkylated quinolines.
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