Successful Treatment of Recalcitrant Palmoplantar Pustulosis with Ixekizumab

Palmoplantar pustulosis (PPP) is a chronic dermatosis that is often viewed as difficult to treat and manage. Many treatment modalities exist for PPP, starting with topical agents and moving to systemic medications in recalcitrant cases. We describe a patient with PPP who was initiated on ixekizumab following failure of several treatment modalities. After 3 months of using ixekizumab, the patient experienced significant improvement of symptoms with no reported side effects. This case demonstrates ixekizumab as an option in cases of recalcitrant PPP. To our knowledge, this is the first reported case of treatment success using ixekizumab monotherapy for PPP.