医学
冲程(发动机)
肾脏疾病
透析
内科学
心房颤动
肾功能
重症监护医学
高磷血症
心脏病学
人口
高同型半胱氨酸血症
风险因素
机械工程
环境卫生
工程类
作者
Birva Shah,Priya Jagtap,Deepaneeta Sarmah,Aishika Datta,Swapnil Raut,Ankan Kumar Sarkar,Mariya Bohra,Upasna Singh,Falguni Baidya,Kiran Kalia,Anupom Borah,Kunjan R. Dave,Dileep R. Yavagal,Pallab Bhattacharya
摘要
Abstract Stroke is an event causing a disturbance in cerebral function leading to death and disability worldwide. Both acute kidney injury and chronic kidney disease (CKD) are associated with an increased risk of stroke and cerebrovascular events. The underlying mechanistic approach between impaired renal function and stroke is limitedly explored and has attracted researchers to learn more for developing therapeutic intervention. Common risk factors such as hypertension, hyperphosphatemia, atrial fibrillation, arteriosclerosis, hyperhomocysteinemia, blood‐brain barrier disruption, inflammation, etc. are observed in the general population, but are high in renal failure patients. Also, risk factors like bone mineral metabolism, uremic toxins, and anemia, along with the process of dialysis in CKD patients, eventually increases the risk of stroke. Therefore, early detection of risks associated with stroke in CKD is imperative, which may decrease the mortality associated with it. This review highlights mechanisms by which kidney dysfunction can lead to cerebrovascular events and increase the risk of stroke in renal impairment.
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