异黄酮素
分子内力
戒指(化学)
去甲基化
立体化学
化学
串联
转化(遗传学)
化学转化
组合化学
有机化学
生物化学
材料科学
DNA甲基化
复合材料
基因表达
基因
作者
Phaladi Kunyane,Molahlehi S. Sonopo,Mamoalosi A. Selepe
标识
DOI:10.1021/acs.jnatprod.9b00681
摘要
The unexpected conversion of benzoylbenzofurans into isoflavones through an intramolecular cascade that involves deprotection and ring-opening/cyclization is described. This was discovered in an investigation of the possible transformation of benzoylbenzofurans into coumaronochromones. This route affords isoflavones in two major steps from acetophenones and benzoquinones. The transformation was validated by synthesizing differently substituted isoflavone derivatives and further applied to a concise synthesis of a potential anticancer lead compound, glaziovianin A (1).
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