Research progress of protease-activated receptor 1 and diseases

Protease-activated receptor 1 (PAR1) is a subfamily of the G protein-coupled receptors, which is mainly distributed in the circulatory, nervous and digestive systems. PAR1 is mainly involved in hemostasis, memory formation, synaptic plasticity as well as gastrointestinal motility and secretion. With further research in recent years, it was found that PAR1 played a key role in development and progress of cardiovascular, neurological, neoplastic inflammatory diseases. Lucubrating the dynamic changes and molecular mechanisms of PAR1 in the development of diseases and designing specific drugs based on PAR1 is of great significance for the diagnosis and treatment of PAR1-related diseases. This article systematically reviews the structure, distribution characteristics, biological functions of PAR1 and its role in the development of the disease, intended to provide researchers in the field of medicine with a deeper understanding of PAR1 in the development of diseases, so as to provide new ideas for the treatment of PAR1 related diseases. Key words: Protease-activated receptor 1; Nervous system; Circulatory system; Inflammation; Tumor