介孔二氧化硅
药物输送
纳米技术
纳米生物技术
纳米医学
纳米颗粒
癌症治疗
生物分子
材料科学
癌症
化学
介孔材料
医学
生物化学
内科学
催化作用
作者
Berrin Küçüktürkmen,Jessica M. Rosenholm
标识
DOI:10.1007/978-3-030-58174-9_5
摘要
Mesoporous silica nanoparticles (MSNs) offer many advantageous properties for applications in the field of nanobiotechnology. Loading of small molecules into MSNs is straightforward and widely applied, but with the upswing of both research and commercial interest in biological drugs in recent years, also biomacromolecules have been loaded into MSNs for delivery purposes. MSNs possess many critical properties making them a promising and versatile carrier for biomacromolecular delivery. In this chapter, we review the effects of the various structural parameters of MSNs on the effective loading of biomacromolecular therapeutics, with focus on maintaining stability and drug delivery performance. We also emphasize recent studies involving the use of MSNs in the delivery of biomacromolecular drugs, especially for cancer treatment.
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