HIFU treatment for fibroadenoma - a clinical study at National Scientific Research Centre, Astana, Kazakhstan.

This randomized controlled study evaluated effect of low frequency high intensity focused ultrasound (HIFU) in 80 women with breast fibroadenomas randomly and evenly divided into main and control groups, treated with HIFU and sectoral resection accordingly. In- vitro trial of fibroadenoma samples exposed to different power levels:100 Watt (W), 200 W and 300 W, analysis of results shown that optimal ablation power 200W was enough for coagulation necrosis of tumour, while 300W ablation caused complete destruction of tissues. Results showed that 20% of control group (surgically treated) patients had post-operative complications and 12.5% - postponed recurrences, as opposed to zero incidence of either in the main group (HIFU treated). The average hospital stay following HIFU reduced by 52%. Both in-vitro and morphological studies showed that HIFU caused high precision coagulation necrosis of fibroadenoma and preservation of the surrounding tissues. HIFU enabled to avoid early postoperative complications and long-term recurrences. This technique can significantly improve quality of life by reducing pain intensity and enabling sooner activity..