受体
细胞外
三磷酸腺苷
溶解
P2受体
细胞溶解
细胞生物学
生物物理学
生物化学
生物
化学
分子生物学
嘌呤能受体
体外
细胞毒性
作者
Annmarie Surprenant,François Rassendren,Eric Kawashima,Richard North,Gary Buell
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1996-05-03
卷期号:272 (5262): 735-738
被引量:1639
标识
DOI:10.1126/science.272.5262.735
摘要
The P2Z receptor is responsible for adenosine triphosphate (ATP)-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Other ATP-gated channels, the P2X receptors, are permeable only to small cations. Here, an ATP receptor, the P2X7 receptor, was cloned from rat brain and exhibited both these properties. This protein is homologous to other P2X receptors but has a unique carboxyl-terminal domain that was required for the lytic actions of ATP. Thus, the P2X7 (or P2Z) receptor is a bifunctional molecule that could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
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