化学
烷基
卤化物
硫醚
电泳剂
铜
三氟甲基
有机化学
溶剂
药物化学
高分子化学
催化作用
作者
Quanfu Lin,Li Chen,Yangjie Huang,Mingguang Rong,Yaofeng Yuan,Zhiqiang Weng
摘要
A general and convenient copper-mediated trifluoromethylthiolation of primary and secondary alkyl halides was described. Variation of the solvent, additives and time allowed optimization of the reaction. A wide range of alkyl halides were explored to give a set of alkyl trifluoromethyl thioethers in moderate to excellent yields. A variety of functional groups, including ethers, thioether, esters, nitriles, amides, and ketal groups, were well tolerated in the electrophilic partner.
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