复式(建筑)
连接器
核酸
化学
脱氧腺苷
组合化学
DNA
热稳定性
有机化学
生物化学
计算机科学
操作系统
作者
Di Zhang,Yamin Li,Liang Xu,Maosheng Cheng,Ying Zhou,Junlin He,Keliang Liu
标识
DOI:10.1080/15257770.2010.510124
摘要
Tert-butyldiphenylsilyl (TBDPS) was testified to be an appropriate orthogonal protecting group for novel 7-hydroxyl-functionalized 8-aza-7-deaza-2′-deoxyadenosine analogues. It was stable in partial and complete hydrogenation reactions used for the different linker preparation. The corresponding phosphoramidites and hydroxyl-functionalized oligodeoxynucleotides were synthesized and identified. The thermal effect of the hydroxyl group with different linkers on DNA duplexes was evaluated. It provided a feasible strategy for the preparation of hydroxyl-functionalized DNAs for the nucleic acid research.
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