PROGRESSION OF TGF-β/SMAD SIGNALING PATHWAY AND TGF-β_1 AND SMAD4 IN CERVICAL CARCINOMA

The transforming growth factor-β(TGF-β)/smad signaling pathway has an important role in carcinogenesis.In recent years,many investigations have revealed that TGF-β super-family ligands,receptors,smads protein,up stream and down stream regulators and cross-talk among many signaling pathways function in the correlative cancer.This review attempts to state transforming growth factor-β/smad signaling pathway and factor-β1、smad4 in cervical carcinoma.