Using organic amine as primer,propylene oxide(PO) and epoxy ethane(EO) as monomer,potassium hydroxide as catalyst,the AE multi-block polyether demulsifiers are synthesized at less than 0.5 MPa and at(130±5)℃ for PO and at(120±5)℃ for EO.Dehydration experiments of the demulsifiers have been conducted at 55℃ with demulsifier concentration of 100 mg·L-1 for Nianzhuang crude oil and at 65℃ with demulsifier concentration of 200 mg·L-1 for Zichang crude oil in Shanbei Oilfield.It is found that the dehydration rate of AE1616 is 97.1%,and dehydration speed is rapid,separated water is clear,interface between oil and water is homogeneous to the crude oil of Nianzhuang;the dehydration rate of AE162 is 93.2%,and dehydration speed is slow,separated water is clear,interface between oil and water is homogeneous to the crude oil of Zichang.