Objective To evaluate the results in implementation of the strategy for dealing with the plague at late stage in endemic areas of Guangxi Autonomous Region. Methods The Results of surveillance and treatment of plague in Guangxi in 2000~2003 were analyzed and assessed. Results In the last 4 years the number of plague cases in this Region was dropped from 42 in 2000 to 0 in 20003 and the detective rate of Yersinia pestis reduced from 0.19% in 2000 to 0 in 2003 and the positive rate of F1antibody against Yersinia pestis reduced from 0.38% in 2000 to 0.01% in 2003. Conclusion The strategy in management of plague implemented at late stage is markedly effective for control of plague and it is worthy of popularization in other endemic areas.