Objective To investigate the characteristics of acute infarction in different locations.Methods A retrospective study was carried out in the patients with acute myocardial infarction. The patients were divided into different groups according to the infarction walls.Results There were 1 827 patients who matched the diagnosis criterion of acute myocardial infarction. The patients with infarction of the anterior wall accounted for 45.8 %, while 26.7 % were infarction of the inferior wall. Among all the groups, the incidences in male patients ranging from 64.0% to 88.3% were higher than those of the female patients with 11.7% to 36.0%. There was significant difference between males and females (P0.05).The group of acute myocardial infarction with both anterior and inferior walls had a significant higher mortality than the average mortality (P0.05).Conclusion Anterior or inferior wall of the ventricle were the two most common of myocardial infarction.Male had the higher risk of acute myocaridial infarctions. Patients with acute infarction of both anterior and inferior walls have a markedly increased mortality.