Research progress in synthesis of caffeic acid phenyethyl ester

Caffeic acid phenethyl ester with anti-cancer activity has attracted considerable attention.Synthetic routes and its catalytic mechanisms of caffeic acid phenethyl ester from different substrates are reviewed.The bio-synthetic characteristics by chlorogenate hydrolase and lipase are mainly discussed,respectively.The development trends and prospects of synthetic methods related with caffeic acid phenethyl ester are looked forward to.