菁
铜
荧光
材料科学
选择性
尿
肝硬化
生物
胃肠病学
医学
生物化学
光学
冶金
物理
催化作用
作者
Yibing Shi,Rou‐Min Wang,Wei Yuan,Qingyun Liu,Minxian Shi,Wei Feng,Zhi‐Ying Wu,Ke Hu,Fuyou Li
标识
DOI:10.1021/acsami.8b07081
摘要
Copper(II) is one of the essential metal elements in human body, which can accumulate in many organs and finally excrete in urine. Excessive load of Cu2+ can cause liver cirrhosis, kidney dysfunction, and many neurological symptoms in the case of Wilson’s disease (WD). Therefore, the selective and efficient detection of Cu2+ is of great importance. Although various fluorescent probes have been reported for the detection of Cu2+, an efficient and capable probe is still rare for patients’ self-use on a routine basis. In this study, we developed an easy-to-use probe CY1 based on UV–vis–near-infrared absorption changes with excellent sensitivity and selectivity for Cu2+. The mechanism of oxidation of CY1 by Cu2+ was first explored. We demonstrated the role of the probe in the quantitative detection of Cu2+ in urine from WD patients and showed that it has great potential for clinical applications.
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