Synthesis of a Bifunctional Ligand for the Sequential Enantioselective Catalysis of Various Reactions

A new bifunctional ligand capable of promoting various enantioselective catalytic transformations has been prepared by connecting a bis(oxazoline) to dihydroquinidine via a spacer. This ligand has been employed in a one-pot procedure, in which the asymmetric cyclopropanation and dihydroxylation of styrene were accomplished in a sequential fashion with good enantioselectivity.