透皮
纳米医学
药物输送
癌症治疗
医学
材料科学
纳米技术
药理学
药品
纳米颗粒
毒品携带者
癌症
内科学
作者
Minglong Chen,Guilan Quan,Ying Sun,Dan Yang,Xin Pan,Chuanbin Wu
标识
DOI:10.1016/j.jconrel.2020.06.039
摘要
Polymeric microneedles (MNs) have been leveraged as a novel transdermal drug delivery platform for effective drug permeation, which were widely used in the treatment of various diseases. However, issues including limited loading capacity of hydrophobic drugs, uncontrollable drug release rates, and monotonic therapeutic strategy hamper the further application of polymeric MNs. As a recent emerging research topic, drawing inspiration from the ways that nanomedicine integrated with MNs have opened new avenues for disease therapy. In this review, we examined the recent studies employing nanoparticles (NPs)-encapsulated polymeric MNs ([email protected]) for transdermal delivery of various therapeutic cargos, particularly focused on the application of [email protected] for diabetes therapy, infectious disease therapy, cancer therapy, and other dermatological disease therapy. We also provided an overview of the clinical potential and future translation of [email protected]
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