Eosinophil-associated dermatoses

Eosinophils induce tissue damage and organ dysfunction mainly through antigen-antibody reactions, release of toxic granules, mitochondrial DNA, and so on. Skin lesions induced by eosinophilia include erythema, plaques and nodules, usually with itching. Eosinophilia may manifest as an increase of eosinophil count in peripheral blood and eosinophilic infiltration of organs and tissues. Diseases associated with eosinophilia in both peripheral blood and the skin include hypereosinophilic syndrome, Churg-Strauss syndrome, Kimura′s disease, Wells′ syndrome, etc. Dermatoses associated with eosinophilia in peripheral blood alone include allergic cutaneous vasculitis, drug reaction with eosinophilia and systemic symptoms, etc, and those associated with eosinophilia in the skin alone include angiolymphoid hyperplasia with eosinophilia, pemphigoid gestationis, incontinentia pigmenti, etc. Key words: Eosinophilia; Skin diseases; Churg-Strauss syndrome; Inflammation; Immunity