Exploring the hydrogen bond enhanced halogen bond

The hydrogen bond enhanced halogen bond (HBeXB) is a newly discovered synergistic relationship between hydrogen bonds (HBs) and halogen bonds (XBs).The HBeXB represents a unique method of tuning a XB by positioning a HB donor(s) proximal to the electron-rich belt of a XB donor.The HB further polarizes the electron density of the XB donor, making the XB stronger.This relationship was simultaneously demonstrated in our supramolecular chemistry group 1 and a biochemistry group 2 , highlighting the far-reaching and diverse impact of the HBeXB.