钠通道
内质网
导航1.5
导航1
细胞生物学
高尔基体
化学
膜电位
弗莱卡奈德
门控
离子通道
生物物理学
钠
医学
膜片钳
内科学
钠通道阻滞剂
电压门控离子通道
心室动作电位
心脏病学
心脏动作电位
电生理学
钾通道
作者
Caijuan Dong,Ya Wang,Aiqun Ma,Tingzhong Wang
标识
DOI:10.3389/fphys.2020.609733
摘要
Cardiac voltage-gated sodium channel Na V 1.5, encoded by SCN5A , is crucial for the upstroke of action potential and excitation of cardiomyocytes. Na V 1.5 undergoes complex processes before it reaches the target membrane microdomains and performs normal functions. A variety of protein partners are needed to achieve the balance between SCN5A transcription and mRNA decay, endoplasmic reticulum retention and export, Golgi apparatus retention and export, selective anchoring and degradation, activation, and inactivation of sodium currents. Subtle alterations can impair Na V 1.5 in terms of expression or function, eventually leading to Na V 1.5-associated diseases such as lethal arrhythmias and cardiomyopathy.
科研通智能强力驱动
Strongly Powered by AbleSci AI