The sigma-2 (σ-2) receptor: a review of recent patent applications: 2013–2018

In 2017, the sigma-2 receptor was positively identified as TMEM97 (transmembrane protein 97). The resolution of this 'identity crisis' will facilitate a greater understanding of the pharmacological role of sigma-2 receptor as well as support the identification of novel sigma-2 receptor ligands with potential utility as disease-modifying therapies.