多发性肌炎
皮肌炎
外周血单个核细胞
医学
间质性肺病
肿瘤坏死因子α
肌炎
白细胞介素
免疫学
免疫系统
白细胞介素6
菲科尔
生物标志物
内科学
自身抗体
抗体
胃肠病学
抗合成酶综合征
炎症
细胞因子
肺
生物
体外
生物化学
作者
Qinglai Jiang,Yuxuan Li,Liping Xia,Hui Shen,Jing Lu
出处
期刊:Journal of Interferon and Cytokine Research
[Mary Ann Liebert]
日期:2019-10-29
卷期号:39 (11): 720-725
被引量:2
标识
DOI:10.1089/jir.2019.0063
摘要
Interleukin (IL)-35 is confirmed as an important modulator in immune response. The aim of the study was to explore the role of IL-35 in the development of polymyositis/dermatomyositis (PM/DM). Ninety-five patients with PM/DM and 30 healthy controls (HCs) were recruited. Peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll-Paque Plus density gradient centrifugation. Protein IL-35, IL-17, and tumor necrosis factor (TNF)-α levels were measured using enzyme-linked immunosorbent assay method. The IL-35 serum levels in PM/DM patients were significantly higher than those in HCs and were correlated with PM/DM-related features: disease activity, muscle damage, and interstitial lung disease (ILD). Exogenous IL-35 notably suppressed lipopolysaccharide-induced IL-17 and TNF-α production in PBMCs of patients with PM/DM. Elevated serum IL-35 levels could act as a disease activity biomarker and an indicator of ILD in PM/DM. IL-35 may play an anti-inflammatory role in PM/DM.
科研通智能强力驱动
Strongly Powered by AbleSci AI