化学
催化作用
三氯氢硅
药物化学
有机化学
组合化学
出处
期刊:Molecules
[MDPI AG]
日期:2019-01-22
卷期号:24 (3): 401-
被引量:6
标识
DOI:10.3390/molecules24030401
摘要
A method for the HMPA (hexamethylphosphoric triamide)-catalyzed metal-free transfer hydrogenation of pyridines has been developed. The functional group tolerance of the existing reaction conditions provides easy access to various piperidines with ester or ketone groups at the C-3 site. The suitability of this method for the reduction of other N-heteroarenes has also been demonstrated. Thirty-three examples of different substrates have been reduced to designed products with 45–96% yields.
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