串联
化学
呋喃
炔烃
组合化学
催化作用
钥匙(锁)
铜
级联反应
药物化学
有机化学
计算机科学
计算机安全
复合材料
材料科学
作者
Danqing Ji,Kai Liu,Jiangtao Sun
出处
期刊:Organic Letters
[American Chemical Society]
日期:2018-11-15
卷期号:20 (23): 7708-7711
被引量:19
标识
DOI:10.1021/acs.orglett.8b03435
摘要
Tandem reactions of copper-catalyzed cross-coupling of N-substituted prop-2-yn-1-amines with diazoacetates and subsequent cyclization have been developed to prepare several types of four- to six-membered heterocycles. Copper-catalyzed allenoate formation has been proven as the key step for the diverse annulations. Importantly, on the basis of the choice of different N-protecting groups of the alkyne substrates, methods toward 5,6-dihydropiperidin-2-ones, 2-methyleneazetidines, and furan derivatives have been well established.
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