过度诊断
肺癌
医学
肺癌筛查
癌症
计算机断层摄影术
肺
放射科
肺癌的治疗
癌症筛查
肿瘤科
内科学
重症监护医学
作者
Hui Zhang,Shucai Zhang
出处
期刊:DOAJ: Directory of Open Access Journals - DOAJ
日期:2016-10-20
卷期号:19 (10): 715-720
被引量:1
标识
DOI:10.3779/j.issn.1009-3419.2016.10.14
摘要
Lung cancer is the leading cause of cancer mortality currently. Early diagnosis is crucial to the good prognosis of lung cancer. Evidence has shown that low-dose computed tomography (CT) screening can make the decline in the mortality of lung cancer. However, there are still many problems in the screening, such as, high false-positive rates, overdiagnosis and radiation exposure. As another non-invasive tumor screening method, blood-based tumor markers showed a high sensitivity and specificity in early diagnosis of lung cancer in recent years. How to establish a comprehensive mode for lung cancer screening by use existing screening methods, we need more clinical research.肺癌是目前恶性肿瘤死亡的首要原因,早期诊断对肺癌的预后至关重要。研究显示低剂量计算机断层扫描(computed tomography, CT)筛查可以使肺癌的死亡率下降。但其存在的问题不可忽视,如过高的假阳性率、过度诊断、辐射效应等。作为一种肿瘤无创筛查方法,血液相关肿瘤标志物的检测,在肺癌早期诊断中显示出良好的敏感性和特异性。如何利用现有的筛查手段,建立肺癌筛查综合模式,需要更多大规模的临床研究。.
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