TCF7L2型
妊娠期糖尿病
SNP公司
单倍型
单核苷酸多态性
医学
荟萃分析
内科学
肿瘤科
妇科
遗传学
基因
生物
怀孕
妊娠期
基因型
作者
Zhi Hou,Ming Li,Yan-Min Cao
标识
DOI:10.1080/09513590.2017.1290066
摘要
Several polymorphisms have been identified in transcription factor 7-like 2 (TCF7L2), and calpain-10 (CAPN10) genes. Controversial conclusions for the genetic relationship between these polymorphisms and gestational diabetes mellitus (GDM) risks were obtained. Our study aims at assessing whether these polymorphisms are associated with GDM susceptibility via a meta-analysis. A total of 19 eligible case-control articles were obtained after databases searching. A significantly increased GDM risk was observed for TCF7L2 rs7903146 (all OR > 1, p < 0.01), but not rs12255372. In addition, significant difference was observed in case/control comparison for 112/112 (GG/2R2R/TT) haplotype combination frequency of CAPN10 SNP-43/19/63 (OR = 3.32, p = 0.043). In summary, TCF7L2 rs7903146 and 112/112 haplotype of CAPN10 might be associated with GDM risks.
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