医学
结直肠癌
药品
药物输送
靶向给药
癌症
化疗
药理学
内科学
纳米技术
材料科学
作者
Antara Banerjee,Surajit Pathak,Vimala Devi Subramanium,Dharanivasan Gunasekaran,Ramachandran Murugesan,Rama Shanker Verma
标识
DOI:10.1016/j.drudis.2017.05.006
摘要
Despite advances in treatment modalities, colon cancer (CC) is the third most common cause of cancer-related death worldwide. Subsequent unfavorable effects owing to toxicity of conventional drugs are a challenging problem associated with chemotherapy. There is noticeable concern toward site-specific/targeted delivery of chemotherapeutic drugs specifically to the affected site of the colon in a predictable and reproducible manner. However, the biggest challenge in successful drug targeting for the colon is avoidance of drug absorption and/or degradation in the upper gastrointestinal tract before the drug reaches the colon. Nanoparticles endowed with targeting abilities offer a novel approach for site-specific delivery of chemotherapeutic agents. The present review focuses on recent approaches for colon-specific drug delivery (CDDS) and aims to unveil the emerging possibilities and advances in the treatment of CC with CDDS.
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