沃尔巴克氏菌
埃及伊蚊
生物
细胞质不亲和性
人口
载体(分子生物学)
人口自然增长
病毒学
生态学
寄主(生物学)
遗传学
环境卫生
幼虫
基因
医学
重组DNA
作者
Zhiyong Xi,Cynthia Khoo,Stephen L. Dobson
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2005-10-14
卷期号:310 (5746): 326-328
被引量:458
标识
DOI:10.1126/science.1117607
摘要
A proposed strategy to aid in controlling the growing burden of vector-borne disease is population replacement, in which a natural vector population is replaced by a population with a reduced capacity for disease transmission. An important component of such a strategy is the drive system, which serves to spread a desired genotype into the targeted field population. Endosymbiotic Wolbachia bacteria are potential transgene drivers, but infections do not naturally occur in some important mosquito vectors, notably Aedes aegypti. In this work, stable infections of wAlbB Wolbachia were established in A. aegypti and caused high rates of cytoplasmic incompatibility (that is, elimination of egg hatch). Laboratory cage tests demonstrated the ability of wAlbB to spread into an A. aegypti population after seeding of an uninfected population with infected females, reaching infection fixation within seven generations.
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