化学
共晶
溶解
尿素
结晶学
Crystal(编程语言)
热分析
乙醇
晶体结构
吸附
粉末衍射
核化学
有机化学
分子
氢键
热的
热力学
吸附
物理
计算机科学
程序设计语言
作者
Hideaki Furuta,Shintaro Mori,Yasuo Yoshihashi,Etsuo Yonemochi,Hidehiro Uekusa,Kiyohiko Sugano,Katsuhide Terada
标识
DOI:10.1016/j.jpba.2015.03.008
摘要
Pranlukast (PRS) is a leukotriene receptor antagonist for the treatment of bronchial asthma. In this study, six new solvates and one new cocrystal of PRS were characterized by PXRD, TG-DTA, DSC, vapor sorption analysis and the dissolution test. In addition, the crystal structures were determined by single crystal X-ray structure analysis. PRS was found to be a rare example of a promiscuous multicomponent crystal former. The crystal packing patterns of these crystals can be categorized into the sheet-like and channel-like patterns. The ethanol solvate (PRS/ethanol) and urea cocrystal (PRS/urea) were more stable than the others under humid conditions. PRS/ethanol showed an improved dissolution profile compared to PRS HH and PRS/urea.
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