幽灵蛋白
EPB41
细胞骨架
脊髓小脑共济失调
细胞生物学
细胞
生物
计算生物学
遗传学
基因
作者
Rui Zhang,Chen-Yu Zhang,Qi Zhao,Donghai Li
标识
DOI:10.1007/s11427-013-4575-0
摘要
Spectrin is a large, cytoskeletal, and heterodimeric protein composed of modular structure of α and β subunits, it typically contains 106 contiguous amino acid sequence motifs called "spectrin repeats". Spectrin is crucial for maintaining the stability and structure of the cell membrane and the shape of a cell. Moreover, it contributes to diverse cell functions such as cell adhesion, cell spreading, and the cell cycle. Mutations of spectrin lead to various human diseases such as hereditary hemolytic anemia, type 5 spinocerebellar ataxia, cancer, as well as others. This review focuses on recent advances in determining the structure and function of spectrin as well as its role in disease.
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