地高辛
心苷
菌群(微生物学)
体内
代谢物
微生物学
真细菌
生物
肠道细菌
细菌
糖苷
胃肠道
抗生素
生物化学
化学
医学
内科学
哇巴因
心力衰竭
遗传学
植物
生物技术
有机化学
钠
作者
' Saha,VP Butler,Neu Hc,John Lindenbaum
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1983-04-15
卷期号:220 (4594): 325-327
被引量:213
标识
DOI:10.1126/science.6836275
摘要
Digoxin, the most widely used cardiac glycoside, undergoes significant metabolic conversion in many patients to cardioinactive metabolites in which the lactone ring is reduced. This appears to occur within the gastrointestinal tract. An attempt was made to isolate and identify the organisms capable of reducing digoxin from stool cultures obtained from human volunteers. Of hundreds of isolates studied, only Eubacterium lentum, a common anaerobe of the human colonic flora, converted digoxin to reduced derivatives. Such organisms were also isolated in high concentrations from the stools of individuals who did not excrete these metabolites when given digoxin in vivo. When the growth of E. lentum was stimulated by arginine, inactivation of digoxin was inhibited. Neither the presence of these organisms alone nor their concentration within the gut flora appeared to determine whether digoxin would be inactivated by this pathway in vivo.
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