透皮
超声波
药物输送
纳米技术
皮下注射针
生物医学工程
医学
材料科学
药理学
精神科
放射科
注射器
作者
Matthias A. Oberli,Carl M. Schoellhammer,Robert Langer,Daniel Blankschtein
出处
期刊:Therapeutic Delivery
[Newlands Press Ltd]
日期:2014-10-07
卷期号:5 (7): 843-857
被引量:50
摘要
The skin is a formidable diffusion barrier that restricts passive diffusion to small (<500 Da) lipophilic molecules. Methods used to permeabilize this barrier for the purpose of drug delivery are maturing as an alternative to oral drug delivery and hypodermic injections. Ultrasound can reversibly and non-invasively permeabilize the diffusion barrier posed by the skin. This review discusses the mechanisms of ultrasound-permeability enhancement, and presents technological innovations in equipment miniaturization and recent advances in permeabilization capabilities. Additionally, potentially exciting applications, including protein delivery, vaccination, gene therapy and sensing of blood analytes, are discussed. Finally, the future challenges and opportunities associated with the use of ultrasound are discussed. It is stressed that developing ultrasound for suitable applications is key to ensure commercial success.
科研通智能强力驱动
Strongly Powered by AbleSci AI