Rhodium-Catalyzed C–H Bond Functionalization with Amides by Double C–H/C–N Bond Activation

The first C–H bond functionalization with amides as the coupling partners via selective activation of the amide N–C bond using rhodium(I) catalysts under highly chemoselective conditions is reported. Notably, this report constitutes the first catalytic activation of the amide N–C(O) bond by rhodium. We expect that this concept will have broad implications for using amides as coupling partners for C–H activation beyond the work described herein.